IMPACT OF CNIDOSCOLUS ACONITIFOLIUS ON HEMATOLOGICAL PARAMETERS IN RATS

Abstract

The plant Chindoscolus aconitifolius or often called Japanese papaya contains secondary metabolite compounds such as saponins, flavonoids, tannins, alkaloids, phytates, cyanogenic glycosides, and terpenoi. C. aconitifolius toxicity test on erythrocytes, leukocytes, and thrombocytes has never been done. The purpose of this study was to determine the effect C. aconitifolius leaves ethanol extract on erythrocytes, leukocytes, and thrombocytes in rats. Twhis research method uses experimental laboratory post-test. Tests on 24 female rats (Rattus Norvegicus) which were divided into 4 groups with 6 rats each. In the division of groups consisting of groups given 1% Na CMC (negative control), 50 mg/kg bw, 300 mg/kg bw and 2000 mg/kg bw carried out for 14 days. Statistically, the results showed no significant effect on the number of erythrocytes (p-value=0.338), leukocytes (p-value=0.750), and Thrombocytes (p-value=0.456). This study can be concluded that there is no toxic effect of C. aconitifolius Leaf Ethanol Extract on erythrocytes, leukocytes, and thrombocytes in rats (Rattus norvegicus).